Back to Siren, L.L.C.

Siren, L.L.C.

Q2 2026 13F filing

Updated 28 days ago

119 disclosed positions worth $4.9B

Portfolio value
$4.9B
Total holdings
119
New positions
0
Closed positions
0
Increased
0
Decreased
0
Turnover
Filed
2026-08-13

Full holdings

Every line item disclosed in Q2 2026

S

Scholar Rock Holding Corp

Value
$526.6M
Shares
9.58M
% Port
10.66%
K

Kymera Therapeutics Inc

Value
$336.7M
Shares
2.94M
% Port
6.81%
E
3.EQR

Erasca Inc

Value
$208.8M
Shares
11.40M
% Port
4.23%
M

Veradermics Inc

Value
$203.5M
Shares
1.66M
% Port
4.12%
T

Tango Therapeutics Inc

Value
$193.2M
Shares
6.18M
% Port
3.91%
R

Revolution Medicines Inc

Value
$168.6M
Shares
900.0K
% Port
3.41%
B

Bicara Therapeutics Inc

Value
$166.4M
Shares
5.60M
% Port
3.37%
A

Arrowhead Pharmaceuticals Inc

Value
$139.8M
Shares
1.72M
% Port
2.83%
B

BeOne Medicines AG

Value
$132.5M
Shares
465.0K
% Port
2.68%
E
10.EWTX

Edgewise Therapeutics Inc

Value
$129.4M
Shares
3.18M
% Port
2.62%
R
11.RYTM

Rhythm Pharmaceuticals Inc

Value
$126.2M
Shares
1.14M
% Port
2.55%
L
12.LXRX

Lexicon Pharmaceuticals Inc

Value
$106.3M
Shares
44.30M
% Port
2.15%
E
13.ELVN

Enliven Therapeutics Inc

Value
$90.1M
Shares
1.77M
% Port
1.82%
S
14.SYRE

Spyre Therapeutics Inc

Value
$86M
Shares
968.6K
% Port
1.74%
P
15.PBLS

Parabilis Medicines Inc

Value
$81.9M
Shares
2.99M
% Port
1.66%
X
16.XENE

Xenon Pharmaceuticals Inc

Value
$79.6M
Shares
1.32M
% Port
1.61%
S
17.SLDB

Solid Biosciences Inc

Value
$76.8M
Shares
7.69M
% Port
1.55%
A

Abivax SA

Value
$76.8M
Shares
576.0K
% Port
1.55%
C
19.COAG

Hemab Therapeutics Holdings Inc

Value
$76.6M
Shares
2.09M
% Port
1.55%
C
20.COGT

Cogent Biosciences Inc

Value
$72M
Shares
1.86M
% Port
1.46%
R
21.RLAY

Relay Therapeutics Inc

Value
$68.3M
Shares
3.65M
% Port
1.38%
T
22.TSHA

Taysha Gene Therapies Inc

Value
$67.1M
Shares
9.85M
% Port
1.36%
D
23.DFTX

Definium Therapeutics Inc

Value
$66.8M
Shares
1.42M
% Port
1.35%
S
24.STOK

Stoke Therapeutics Inc

Value
$65.3M
Shares
2.00M
% Port
1.32%
I
25.IRON

Disc Medicine Inc

Value
$65M
Shares
888.4K
% Port
1.31%
C
26.CYTK

Cytokinetics Inc

Value
$64.7M
Shares
759.0K
% Port
1.31%
S
27.SEPN

Septerna Inc

Value
$63.6M
Shares
1.90M
% Port
1.29%
O
28.OLMA

Olema Pharmaceuticals Inc

Value
$60.8M
Shares
4.86M
% Port
1.23%
R
29.RCUS

Arcus Biosciences Inc

Value
$53.8M
Shares
1.75M
% Port
1.09%
C
30.CRNX

Crinetics Pharmaceuticals Inc

Value
$53.2M
Shares
1.42M
% Port
1.08%
K
31.KLRA

Kailera Therapeutics Inc

Value
$48.8M
Shares
2.21M
% Port
0.99%
D
32.DYN

Dyne Therapeutics, Inc

Value
$47.3M
Shares
2.13M
% Port
0.96%
G
33.GPCR

Structure Therapeutics Inc

Value
$46.9M
Shares
873.0K
% Port
0.95%
T
34.TBLA

Taboola.com Ltd

Value
$42.1M
Shares
8.42M
% Port
0.85%
P
35.PVLA

Palvella Therapeutics Inc

Value
$39.3M
Shares
257.5K
% Port
0.80%
S

Silence Therapeutics PLC

Value
$36.4M
Shares
3.31M
% Port
0.74%
D
37.DNLI

Denali Therapeutics Inc

Value
$35.9M
Shares
1.40M
% Port
0.73%
R
38.RELY

Remitly Global Inc

Value
$34.6M
Shares
1.54M
% Port
0.70%
C
39.CGEM

Cullinan Therapeutics Inc

Value
$34.5M
Shares
1.89M
% Port
0.70%
C

Capital One Finl Corp

Value
$34.4M
Shares
171.6K
% Port
0.70%
T
41.TRVI

Trevi Therapeutics Inc

Value
$33.3M
Shares
1.79M
% Port
0.67%
G

Alphabet Inc

Value
$32.2M
Shares
90.0K
% Port
0.65%
D

Dbv Technologies SA

Value
$30.5M
Shares
1.86M
% Port
0.62%
A
44.ABSI

Absci Corp

Value
$28.7M
Shares
2.47M
% Port
0.58%
S
45.SION

Sionna Therapeutics Inc

Value
$26.9M
Shares
610.5K
% Port
0.54%
R
46.RAPP

Rapport Therapeutics Inc

Value
$26.7M
Shares
641.5K
% Port
0.54%
A
47.AMLX

Amylyx Pharmaceuticals Inc

Value
$26.6M
Shares
1.48M
% Port
0.54%
A
48.ANNX

Annexon Inc

Value
$25.5M
Shares
4.46M
% Port
0.52%
M
49.MNPR

Monopar Therapeutics Inc

Value
$25M
Shares
270.1K
% Port
0.51%
O
50.ORKA

Oruka Therapeutics Inc

Value
$23.8M
Shares
250.0K
% Port
0.48%