PERCEPTIVE ADVISORS LLC

hedge fundUpdated 28 days ago

Managed by Perceptive Advisors Llc • Latest filing Q2 2026

Portfolio value

$6.7B

Q2 2026

Filings

13

Quarterly 13F history

Top-10 concentration

47.3%

Weight of largest holdings

Annualized return

24.5%

Implied from 13F holdings

Portfolio value history

13F-disclosed portfolio value over 14 quarters

Show data table

Period	Portfolio value
Q1 2023	$3.4B
Q2 2023	$3.4B
Q3 2023	$3B
Q4 2023	$4.5B
Q1 2024	$5.8B
Q2 2024	$4.2B
Q3 2024	$4.7B
Q4 2024	$3.6B
Q1 2025	$2.8B
Q2 2025	$2.7B
Q3 2025	$3.5B
Q4 2025	$5.6B
Q1 2026	$5.1B
Q2 2026	$6.7B

Top holdings

109 positions as of Q2 2026

#	Stock	Value	Shares	% Portfolio	Change
1	P PRAX PRAXIS PRECISION MEDICINES I	$681.6M	2.04M	10.23%	Unchanged
2	S SYRE SPYRE THERAPEUTICS INC	$383.5M	4.32M	5.76%	Added(+14.2%)
3	C CELC CELCUITY INC	$334.5M	3.20M	5.02%	Added(+2.2%)
4	A ASND ASCENDIS PHARMA A/S	$310.4M	1.16M	4.66%	—
5	R RYTM RHYTHM PHARMACEUTICALS INC	$287.2M	2.59M	4.31%	Added(+8.9%)
6	R ROIV ROIVANT SCIENCES LTD	$286.1M	8.09M	4.30%	Trimmed(-2.4%)
7	R RLAY RELAY THERAPEUTICS INC	$263.9M	14.11M	3.96%	Added(+44.7%)
8	T TVTX TRAVERE THERAPEUTICS INC	$213.2M	3.75M	3.20%	Trimmed(-9.4%)
9	? N/A KARDIGAN INC	$195.6M	8.20M	2.94%	—
10	? N/A NUVALENT INC	$195.2M	1.58M	2.93%	Unchanged
11	E EWTX EDGEWISE THERAPEUTICS INC	$177.7M	4.37M	2.67%	Trimmed(-1.1%)
12	A APGE APOGEE THERAPEUTICS INC	$173.6M	1.31M	2.61%	Trimmed(-15.1%)
13	A AMLX AMYLYX PHARMACEUTICALS INC	$149.7M	8.33M	2.25%	Added(+0.6%)
14	M MGTX MEIRAGTX HLDGS PLC	$145.7M	10.79M	2.19%	Added(+4.5%)
15	O ORKA ORUKA THERAPEUTICS INC	$128M	1.35M	1.92%	Trimmed(-3.6%)
16	I INBX INHIBRX BIOSCIENCES INC	$123M	1.30M	1.85%	Trimmed(-10.1%)
17	P PB PROTAGONIST THERAPEUTICS INC	$120.4M	981.9K	1.81%	Trimmed(-20.2%)
18	S SLDB SOLID BIOSCIENCES INC	$118.9M	11.91M	1.79%	Unchanged
19	Z ZYME ZYMEWORKS INC	$109.3M	4.18M	1.64%	Added(+19.2%)
20	T TNGX TANGO THERAPEUTICS INC	$105.6M	3.38M	1.58%	Added(+317.9%)

P

PRAXIS PRECISION MEDICINES I

Unchanged

Value

$681.6M

Shares

2.04M

% Port

10.23%

S

SPYRE THERAPEUTICS INC

+14.2%

Value

$383.5M

Shares

4.32M

% Port

5.76%

C

CELCUITY INC

+2.2%

Value

$334.5M

Shares

3.20M

% Port

5.02%

A

ASCENDIS PHARMA A/S

Value

$310.4M

Shares

1.16M

% Port

4.66%

R

RHYTHM PHARMACEUTICALS INC

+8.9%

Value

$287.2M

Shares

2.59M

% Port

4.31%

R

ROIVANT SCIENCES LTD

-2.4%

Value

$286.1M

Shares

8.09M

% Port

4.30%

R

RELAY THERAPEUTICS INC

+44.7%

Value

$263.9M

Shares

14.11M

% Port

3.96%

T

TRAVERE THERAPEUTICS INC

-9.4%

Value

$213.2M

Shares

3.75M

% Port

3.20%

?

9.N/A

KARDIGAN INC

Value

$195.6M

Shares

8.20M

% Port

2.94%

?

10.N/A

NUVALENT INC

Unchanged

Value

$195.2M

Shares

1.58M

% Port

2.93%

E

EDGEWISE THERAPEUTICS INC

-1.1%

Value

$177.7M

Shares

4.37M

% Port

2.67%

A

APOGEE THERAPEUTICS INC

-15.1%

Value

$173.6M

Shares

1.31M

% Port

2.61%

A

AMYLYX PHARMACEUTICALS INC

+0.6%

Value

$149.7M

Shares

8.33M

% Port

2.25%

M

MEIRAGTX HLDGS PLC

+4.5%

Value

$145.7M

Shares

10.79M

% Port

2.19%

O

ORUKA THERAPEUTICS INC

-3.6%

Value

$128M

Shares

1.35M

% Port

1.92%

I

INHIBRX BIOSCIENCES INC

-10.1%

Value

$123M

Shares

1.30M

% Port

1.85%

P

17.PB

PROTAGONIST THERAPEUTICS INC

-20.2%

Value

$120.4M

Shares

981.9K

% Port

1.81%

S

SOLID BIOSCIENCES INC

Unchanged

Value

$118.9M

Shares

11.91M

% Port

1.79%

Z

ZYMEWORKS INC

+19.2%

Value

$109.3M

Shares

4.18M

% Port

1.64%

T

TANGO THERAPEUTICS INC

+317.9%

Value

$105.6M

Shares

3.38M

% Port

1.58%

View full portfolio (109 holdings) →

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