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ORBIMED ADVISORS LLC

Q2 2026 13F filing

Updated 28 days ago

129 disclosed positions worth $5.4B

Portfolio value
$5.4B
Total holdings
129
New positions
35
Closed positions
21
Increased
32
Decreased
26
Turnover
43.4%
Filed
2026-08-14

Full holdings

Every line item disclosed in Q2 2026

E

EDGEWISE THERAPEUTICS INC

Unchanged
Value
$630.5M
Shares
15.52M
% Port
11.68%
E

ENLIVEN THERAPEUTICS INC

-14.9%
Value
$343.9M
Shares
6.78M
% Port
6.37%
L
3.LLY

ELI LILLY & CO

+8.9%
Value
$309.3M
Shares
257.9K
% Port
5.73%
M
4.MBX

MBX BIOSCIENCES INC

-5.8%
Value
$189.3M
Shares
3.43M
% Port
3.51%
S
5.SVA

SINOVAC BIOTECH LTD

Unchanged
Value
$184.5M
Shares
2.72M
% Port
3.42%
A
6.AZN

ASTRAZENECA PLC

+36.6%
Value
$171.1M
Shares
915.7K
% Port
3.17%
G

STRUCTURE THERAPEUTICS INC

+49.8%
Value
$118.6M
Shares
2.21M
% Port
2.20%
S

SIONNA THERAPEUTICS INC

-27.6%
Value
$112.4M
Shares
2.56M
% Port
2.08%
C

CORVUS PHARMACEUTICALS INC

Unchanged
Value
$107M
Shares
7.17M
% Port
1.98%
?
10.N/A

ARRIVENT BIOPHARMA INC

Unchanged
Value
$105.2M
Shares
3.03M
% Port
1.95%
G
11.GH

GUARDANT HEALTH INC

+34.1%
Value
$87.6M
Shares
583.7K
% Port
1.62%
A
12.ARGX

ARGENX SE

-32.1%
Value
$86.2M
Shares
92.9K
% Port
1.60%
M
13.MRK

MERCK & CO INC

Unchanged
Value
$85.2M
Shares
663.4K
% Port
1.58%
Q
14.QURE

UNIQURE NV

-15.4%
Value
$83.3M
Shares
1.81M
% Port
1.54%
P
15.PRAX

PRAXIS PRECISION MEDICINES I

+33.4%
Value
$77M
Shares
230.1K
% Port
1.43%
E
16.EW

EDWARDS LIFESCIENCES CORP

-32.2%
Value
$75.5M
Shares
834.9K
% Port
1.40%
P
17.PRLD

PRELUDE THERAPEUTICS INC

+25.8%
Value
$73.2M
Shares
13.72M
% Port
1.36%
A

ABIVAX SA

+17.4%
Value
$72.8M
Shares
546.5K
% Port
1.35%
D
19.DYN

DYNE THERAPEUTICS INC

+10.9%
Value
$71.9M
Shares
3.24M
% Port
1.33%
N
20.NTRA

NATERA INC

Unchanged
Value
$71.1M
Shares
262.0K
% Port
1.32%
C
21.CGON

CG ONCOLOGY INC

+2.6%
Value
$69.1M
Shares
972.8K
% Port
1.28%
U
22.UNH

UNITEDHEALTH GROUP INC

Value
$67M
Shares
161.1K
% Port
1.24%
S
23.SVM

ARS PHARMACEUTICALS INC

Unchanged
Value
$66.4M
Shares
8.29M
% Port
1.23%
A
24.ASND

ASCENDIS PHARMA A/S

Value
$65.2M
Shares
244.5K
% Port
1.21%
H
25.HUM

HUMANA INC

Value
$65.2M
Shares
164.1K
% Port
1.21%
C
26.COGT

COGENT BIOSCIENCES INC

+422.0%
Value
$65.1M
Shares
1.68M
% Port
1.21%
B
27.BSX

BOSTON SCIENTIFIC CORP

-37.7%
Value
$63.3M
Shares
1.48M
% Port
1.17%
I
28.ISRG

INTUITIVE SURGICAL INC

-24.3%
Value
$62.8M
Shares
157.9K
% Port
1.16%
M
29.MLYS

MINERALYS THERAPEUTICS INC

+2.8%
Value
$56.9M
Shares
2.11M
% Port
1.05%
O
30.ODTX

ODYSSEY THERAPEUTICS INC

Value
$56.2M
Shares
3.00M
% Port
1.04%
X
31.XENE

XENON PHARMACEUTICALS INC

-15.8%
Value
$53.9M
Shares
892.5K
% Port
1.00%
A
32.ARQT

ARCUTIS BIOTHERAPEUTICS INC

Value
$53.5M
Shares
2.04M
% Port
0.99%
C

BRISTOL-MYERS SQUIBB CO

Unchanged
Value
$53.3M
Shares
925.0K
% Port
0.99%
Q
34.QTTB

Q32 BIO INC

+83.2%
Value
$52.6M
Shares
4.13M
% Port
0.97%
S
35.SYK

STRYKER CORPORATION

-12.8%
Value
$50.1M
Shares
159.1K
% Port
0.93%
C
36.CAI

CARIS LIFE SCIENCES INC

Unchanged
Value
$50M
Shares
2.81M
% Port
0.93%
S

SPDR SERIES TRUST

Value
$47.5M
Shares
300.0K
% Port
0.88%
T
38.TMO

THERMO FISHER SCIENTIFIC INC

+95.0%
Value
$45.5M
Shares
90.7K
% Port
0.84%
P
39.PVLA

PALVELLA THERAPEUTICS INC NE

+484.7%
Value
$44.7M
Shares
292.4K
% Port
0.83%
E
40.ELV

ELEVANCE HEALTH INC FORMERLY

Unchanged
Value
$44.4M
Shares
114.7K
% Port
0.82%
S
41.STTK

SHATTUCK LABS INC

Unchanged
Value
$43.8M
Shares
6.31M
% Port
0.81%
?
42.N/A

UPSTREAM BIO INC

Unchanged
Value
$39.4M
Shares
5.69M
% Port
0.73%
C
43.CRNX

CRINETICS PHARMACEUTICALS IN

Unchanged
Value
$37.4M
Shares
999.0K
% Port
0.69%
R
44.RYTM

RHYTHM PHARMACEUTICALS INC

+2.8%
Value
$35.9M
Shares
322.9K
% Port
0.66%
S
45.SNDX

SYNDAX PHARMACEUTICALS INC

+60.2%
Value
$33.7M
Shares
1.54M
% Port
0.62%
F
46.FBRX

FORTE BIOSCIENCES INC

+31.8%
Value
$33.5M
Shares
1.58M
% Port
0.62%
?
47.N/A

COMPASS THERAPEUTICS INC

Unchanged
Value
$33.3M
Shares
15.22M
% Port
0.62%
N
48.NKTR

NEKTAR THERAPEUTICS

+69.2%
Value
$32.5M
Shares
465.3K
% Port
0.60%
K
49.KRYS

KRYSTAL BIOTECH INC

+20.4%
Value
$30.9M
Shares
83.2K
% Port
0.57%
F
50.FERG

PRELUDE THERAPEUTICS INC

Unchanged
Value
$30.3M
Shares
5.68M
% Port
0.56%