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Opaleye Management Inc.

hedge fundUpdated 27 days ago

Managed by Opaleye Management Inc. • Latest filing Q2 2026

Portfolio value
$1.1B
Q2 2026
Filings
14
Quarterly 13F history
Top-10 concentration
100.0%
Weight of largest holdings
Annualized return
34.8%
Implied from 13F holdings

Portfolio value history

13F-disclosed portfolio value over 14 quarters

Show data table
PeriodPortfolio value
Q1 2023$333.9M
Q2 2023$418.1M
Q3 2023$307.4M
Q4 2023$376.1M
Q1 2024$436.9M
Q2 2024$437.7M
Q3 2024$599.6M
Q4 2024$571.4M
Q1 2025$449.2M
Q2 2025$498.9M
Q3 2025$707.3M
Q4 2025$758M
Q1 2026$759.2M
Q2 2026$1.1B

Top holdings

58 positions as of Q2 2026

View filing
L

LIQUIDIA CORPORATION

Value
$195.1M
Shares
2.45M
% Port
17.67%
E

ETON PHARMACEUTICALS INC

Value
$103.5M
Shares
2.86M
% Port
9.38%
H

HARROW INC

Value
$101.9M
Shares
2.40M
% Port
9.23%
I

DISC MEDICINE INC

Value
$62.5M
Shares
855.0K
% Port
5.66%
U

UROGEN PHARMA LTD

Value
$53M
Shares
1.44M
% Port
4.80%
A

APOGEE THERAPEUTICS INC

Value
$51.8M
Shares
390.0K
% Port
4.69%
M

MEIRAGTX HLDGS PLC

Value
$48M
Shares
3.55M
% Port
4.34%
S

SOL-GEL TECHNOLOGIES LTD

Value
$37.1M
Shares
500.0K
% Port
3.36%
R

REZOLUTE INC

Value
$32.8M
Shares
6.30M
% Port
2.97%
T
10.TGTX

TG THERAPEUTICS INC

Value
$29.4M
Shares
535.0K
% Port
2.66%
?
11.N/A

IMMIX BIOPHARMA INC

Value
$24.2M
Shares
2.35M
% Port
2.19%
?
12.N/A

CRESCENT BIOPHARMA INC.

Value
$23.7M
Shares
1.32M
% Port
2.15%
S
13.STOK

STOKE THERAPEUTICS INC

Value
$22.9M
Shares
700.0K
% Port
2.07%
A
14.ACOG

ALPHA COGNITION INC

Value
$20.9M
Shares
2.90M
% Port
1.89%
E
15.EWTX

EDGEWISE THERAPEUTICS INC

Value
$20.3M
Shares
500.0K
% Port
1.84%
R

REVOLUTION MEDICINES INC

Value
$18.7M
Shares
100.0K
% Port
1.70%
M
17.MNST

MONTE ROSA THERAPEUTICS INC

Value
$18M
Shares
745.0K
% Port
1.63%
A
18.ALMS

ALUMIS INC

Value
$15.5M
Shares
550.0K
% Port
1.40%
C
19.CDXS

CODEXIS INC

Value
$15.3M
Shares
6.79M
% Port
1.39%
Q
20.QCOM

REPLIMUNE GROUP INC

Value
$15.3M
Shares
1.38M
% Port
1.39%

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